miR-23a, miR-146a and miR-301a confer predisposition to Vogt-Koyanagi-Harada syndrome but not to Behcet’s disease
نویسندگان
چکیده
منابع مشابه
miR-23a, miR-146a and miR-301a confer predisposition to Vogt-Koyanagi-Harada syndrome but not to Behcet’s disease
Ninety-eight miRNAs are involved in the immune response. However, the genetic roles of these miRNAs remain unclear in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome. This study aimed to explore the association and functional roles of copy number variants (CNV) in several miRNAs with BD and VKH syndrome. Genotyping of CNVs was examined by TaqMan PCR. The expression of miR-23a, tra...
متن کاملVogt-koyanagi-harada Syndrome
CASE PRESENTATION A 20 year old Asian male was referred with the complaint of decreased vision in both eyes for a year. His past medical and surgical histories were unremarkable. His family history revealed thyroid disease in his mother. Review of systems were remarkable for alopecia and headache at the time when his eye problems began. The first eye exam from his referring ophthalmologist reve...
متن کاملVogt Koyanagi Harada syndrome.
An 11-year-old female girl presented to us with fever of 3 months duration. Additionally she had vitiligo for two years and deafness and alopecia for the last 3 months. Two years ago, the patient had an episode of pain, watering and congestion of both eyes (suggestive of nontraumatic uveitis) for 2 weeks. She responded to therapy in the form of eye drops and oral medication (Ayurvedic medicine)...
متن کاملVogt-Koyanagi-Harada Syndrome
97 Vogt-Koyanagi-Harada syndrome is generally a rare multisystemic autoimmune disorder involving with pigmented structures, such as the eye, meninges, inner ear and skin. The syndrome typically presents as an episode of bilateral panuveitis after prodromal symptoms similar to aseptic meningitis. Auditory disturbances include tinnitus, hearing loss and vertigo. We report the case of a 74-year-ol...
متن کاملVogt-Koyanagi-Harada disease.
Vogt-Koyanagi-Harada disease is a chronic, granulomatous systemic autoimmune disease with manifestations in the ocular, central nervous, auditory, and integumentary systems. The target of attack seems to be antigens associated with melanocytes. Patients are usually of Asian, Middle Eastern, Asian Indian, Native American, or Hispanic ethnicity, and complain of neurologic symptoms quickly followe...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep20057